Trimethylchlorosilane (M3)

chlorotrimethylsilane msds
me3sicl et3n
tmscl reagent




Trimethylchlorosilane is a colorless or light yellow transparent irritating liquid.

CAS No.: 75-77-4

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Technical Data of Trimethylchlorosilane

Testing ItemsTesting Standards
Trimethylchlorosilane /%≥ 99.5
Methyltrichlorosilane /%≤ 0.05
Tetrachlorosilane /%≤ 0.05

Learn more about methyl chlorosilane and dimethyl dichloro silane offered by Zhongtian.

Description of Trimethylchlorosilane

Trimethylchlorosilane is colorless transparent liquid, and it is volatile, easily hydrolyzed in humid air to free hydrochloric acid. It is soluble in benzene, ether and perchloroethylene. Besides, trimethylchlorosilane is flammable, toxic and corrosive. Sealed and stored in a cool and dry place. Store in a low temperature ventilated place, away from fire and heat source. Separate storage and transportation with oxidizers, acids and bases.

Trimethylchlorosilane Uses

Trimethylchlorosilane is mainly used in the production of end-capping agent MM, silazane, cephalosporins antibiotics, active group protectors, etc.

1.Because of the special activity of silicon-halogen bond, a series of organosilicon compounds containing silicon-functional group structure can be synthesized from trimethylchlorosilane, such as trimethylalkoxysilane, hexamethyldisiloxane, hexamethyldisilazane, trimethylcyanosilane, etc. 

2. Trimethylchlorosilane is an excellent reagent for introducing trimethylsilyl groups in organic molecules, which can be used as protective groups for functional groups such as hydroxyl, carboxyl and amino groups. The reaction of connecting and removing trimethylsilyl group has high yield, mild conditions and wide application, so it is widely used in organic synthesis. 

3.Silylated derivatives are obtained by the reaction of certain biochemical samples with trimethylchlorosilane, which have large volatility and enable gas chromatographic analysis of biochemical samples. 

4.Trimethylchlorosilane is used as a capping agent for organosilicon polymers and plays the role of regulating the molecular weight of polymers, especially in the production of silicone oil, which is widely used. 

Storage and Transportation of Trimethylchlorosilane

Storage: Stored in a shady, cool, and ventilated place. It should be kept away from kindling and heat sources, avoid direct sunlight.
Transportation: When transported, avoid rain and direct sunshine.

Health Hazards of Trimethylchlorosilane

Invasion route: inhalation, ingestion, transdermal absorption.

Health hazards of trimethylchlorosilane: Strong irritation to respiratory tract and eyes, skin mucous membrane. Inhalation can cause death due to spasm and edema of larynx and bronchus, chemical pneumonia, pneumonia and pulmonary edema. Exposed workers often have eye pain, tearing, coughing, headache, nausea, vomiting, wheezing, easily agitated, and itchy skin.

Toxicological information and environmental behavior

Hazardous characteristics of trimethylchlorosilane: Flammable, in contact with high heat, open flame or with oxidizing agents, there is a risk of causing combustion and explosion. Release toxic and corrosive fumes when heated or exposed to moisture liberation heat. Corrosive.

Combustion (decomposition) products: carbon monoxide, carbon dioxide, silicon oxide, hydrogen chloride.

Leakage Emergency Treatment of Trimethylchlorosilane

Quickly evacuate personnel from the leaking contaminated area to a safe area, and isolate and strictly limit access. 

Cut off the source of fire. 

It is recommended that emergency response personnel wear self-contained positive pressure respirators and fire protective clothing. 

Do not come into direct contact with the spill. 

Cut off the source of the spill as much as possible and prevent access to restricted spaces such as sewers and drainage ditches. 

Small leakage: mix with sand, dry stone type or soda ash. You can also brush the emulsion with non-flammable dispersant making surface, and dilute the washing solution into the wastewater system. 

Large amount of leakage: Construct a dike or dig a pit to shelter. Cover with foam to reduce vapor disaster. Transfer to tanker or special collector with explosion-proof pump, recycle or transport to waste disposal site for disposal.


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